Raddeanoside R13
Hederacolchiside A1
CAS: 106577-39-3
Molecular Formula: C47H76O16
Raddeanoside R13 - Names and Identifiers
Raddeanoside R13 - Physico-chemical Properties
| Molecular Formula | C47H76O16 |
| Molar Mass | 897.1 |
| Density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 253-255℃ (methanol , water ) |
| Boling Point | 967.2±65.0 °C(Predicted) |
| Specific Rotation(α) | 0 (c, 2.97 in MeOH) |
| Solubility | Soluble in methanol, acetonitrile, ethanol and other solvents, insoluble in petroleum ether. |
| Appearance | White crystal |
| pKa | 4?+-.0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| In vitro study | Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) . |
| In vivo study | hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells. |
Raddeanoside R13 - Reference Information
| biological activity | Hederacolchiside A1 is isolated from Pulsatilla chinensis and induces apoptosis by regulating PI3K/Akt/mTOR signaling pathway, thus inhibiting tumor cell proliferation. Hederacolchiside A1 has anti-schistosomiasis activity and affects parasite viability in vivo and in vitro. |
| target | PI3K Akt mTOR |
| in vitro study | Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) . |
| in vivo study | hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells. |
Last Update：2024-04-09 21:49:45
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Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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